In Silver-Russell Syndrome (SRS) Hypomethylation of the H19/IGF2 imprinted domain on chromosome 11p15 accounts for 50–60% of cases of Silver-Russell Syndrome (SRS), while maternal uniparental disomy of chromosome 7 (MatUPD7) is found in about 10% of cases. This evidence concerns the gene H19 and Silver-Russell syndrome.