In addition, the observed frequencies of NRG1 fusions in other tumor types were 0.25% in esophageal cancer, 0.17% in colorectal cancer, 0.13% in gastric cancer, 0.11% in pancreatic cancer, and 0.05% in liver cancer (Fig. 1a). This evidence concerns the gene NRG1 and familial pancreatic carcinoma.