Although this relationship has been established using both in vitro and in vivo models of cancer, there is no evidence of BRCAm tumor cells being reliant upon cGAS-STING signaling for survival, and inactivation of cGAS-STING signaling only alters the response to PARPi in vivo in presence of a functional immune system and not in vitro. This evidence concerns the gene CGAS and neoplasm.