Notable examples include circHGF, which encodes C-HGF to activate c-MET signaling and promote glioblastoma growth [25], and circZKSCAN1, which suppresses hepatocellular carcinoma through its interaction with FBXW7 and mTOR, thereby inhibiting the PI3K/AKT pathway [26]. Here, AKT1 is linked to hepatocellular carcinoma.