Furthermore, the analysis for single gene in the gene set revealed that low level expression of CD83, HLA-DMB, HLA-DQB1, HLA-DRA or HLA-DRB1, which was also detected in T-DCs (CD83 and MHCII), was significantly correlated with poor prognosis in ALL patients. The gene discussed is HLA-DRA; the disease is acute lymphoblastic leukemia.