NPM1 and acute myelomonocytic leukemia M4: Patient ALMA_10_BM (60 + years, male; coverage 12.16x), clinically presenting acute myelomonocytic leukemia with NPM1 mutation, was predicted as AML with mutated NPM1, confirmed by genomic detection of a NPM1 pathogenic frameshift (c.860_863dupTCTG; p.Trp288fs) (Fig. 6c).