Patient ALMA_1_BM (0–5 years, male; coverage 2.03x), was clinically diagnosed with acute monocytic leukemia (FAB M5, t(9;11)), nanopore based methylation data predicted AML with t(8;16); KAT6A::CREBBP subtype and t(v;11q23); KMT2A-r, with KMT2Ar consistent with pathology diagnosis. This evidence concerns the gene CREBBP and acute monocytic leukemia.