Patient ALMA_2_BM (5–13 years, male; coverage 6.52x), clinical report indicated AML t(8;21)(q22;q22), and DNA methylation demonstrated high-confidence concordance with AML subtype t(8;21); RUNX1::RUNX1T1 which was also confirmed with genomic sequence data (Fig. 6a). Here, RUNX1 is linked to acute myeloid leukemia.