Similar to PROTAC 51, PROTAC 52 exhibits robust cytotoxic activity against several FLT3-ITD mutant AML cells (IC50 = 1.66 nM) by inducing a marked UPS-dependent degradation of the FLT3-ITD protein (DC50 = 41.35 nM). Here, FLT3 is linked to acute myeloid leukemia.