HMGB1 and pachyonychia congenita: Additionally, HMGB1 (High-Mobility Group Box 1) and ADAM9 (A Disintegrin and Metalloproteinase 9) are upregulated in PC and verified as targets for miR-129-5p across digestive malignancies implying more extensive anti-cancer actions and pending additional functional studies in PDAC70,71.