TGFB1 and pachyonychia congenita: Serum miR-129-5p expression was downregulated in PC patients compared to control participants with median fold change 0.16 (P < 0.00001; Fig. 1b), whereas serum lncRNA NEAT1 was elevated in PC patients with median fold change 2.94 (P < 0.00001; Fig. 1a). PC patients had significantly higher levels of serum BCL2 (P < 0.00001; Fig. 1c), TGF-β1 (P = 0.00002; Fig. 1d), CA19-9 (P < 0.00001), and CEA (P < 0.00001) than control subjects (Table 3).