HTT and neurodegenerative disease: We also checked the role of ANKZF1 during mitochondrial stress by single aggregation-prone misfolded proteins as previous literature reported that many proteins, especially neurodegenerative-disease-associated aggregation-prone cytosolic proteins like α-synuclein [56], mutant huntingtin [57] or amyloid β-peptide [58] are found in mitochondrial sub-compartments and lead to mitochondrial stress and dysfunction.