Canonical markers were used to annotate different cell types: malignant cells (COL1A1, IBSP), myeloid cells (CD74, CD14), osteoclasts (CTSK, MMP9), pericytes (RGS5, ACTA2), endothelial cells (PECAM1, VWF), and tumor-infiltrating lymphocytes (CD3D, NKG7) (Supplementary Fig. 1C). This evidence concerns the gene IBSP and neoplasm.