Whole‐exome sequencing of 83 alcohol use disorder patients identified 106,525 SNVs and 19,826 InDels, revealing six genes (CNTNAP3, ZNF683, ALDH2, CCHCR1, ZNF45, ESRRA) with deleterious mutations through comprehensive bioinformatics analysis. The gene discussed is CNTNAP3; the disease is alcohol abuse.