Whole‐exome sequencing of 83 alcohol use disorder patients identified 106,525 SNVs and 19,826 InDels, revealing six genes (CNTNAP3, ZNF683, ALDH2, CCHCR1, ZNF45, ESRRA) with deleterious mutations through comprehensive bioinformatics analysis. This evidence concerns the gene ZNF683 and alcohol abuse.