TOMM40 and hippocampal atrophy: It has been reported that TOMM40 SNPs are associated with LOAD risk,[11, 44, 45] cognitive performance,[11] and hippocampal atrophy.[46] And mitochondrial dysfunction is one of the risk factors for AD.[47] All these drive our attention and force us to investigate whether SENP6 and TOM40 SUMOylation affect AD progress.