SENP6 and laminopathy: SENP6 specifically cleaves polySUMO2/3 chains,[22] regulating DNA repair,[23] apoptosis,[24] senescence,[25] centromere assembly,[26] inflammation,[27] microglial polarization,[28] angiogenesis,[29] and nuclear architecture.[30] Its dysfunction associates with lymphoma,[31] laminopathies,[32] and skeletal aging.[25] However, SENP6's roles in mitochondrial homeostasis remain unexplored.