Additionally, it is observed that CCCP treatment resulted in a decrease of SENP6 within mitochondria fraction, accompanied by increased TOM40 SUMOylation in the brains of 3×Tg‐Alzheimer's disease (AD) mice or Aβ1‐42 peptide‐stimulated cells. Here, TOMM40 is linked to early-onset autosomal dominant Alzheimer disease.