Mechanistically, NAT10 promotes the translation efficiency of ATPase H+ transporting V0 subunit e1 (ATP6V0E1) mRNA in an ac4C‐dependent manner to facilitate ATP6V0E1 expression and vacuolar H+‐ATPase (v‐ATPase) activity, enhancing the lysosomal degradation of E‐cadherin, ultimately accelerating tumor metastasis. The gene discussed is ATP6V0E1; the disease is neoplasm.