F2 and septic peritonitis: In a canine septic peritonitis study, 14% of cases had liver involvement, defined as 2 of the following: TBil > 42 μmol/L (2.5 mg/dL, 10 times the upper RI limit in the current study), alanine aminotransferase > twice the RI upper limit, prothrombin time or activated partial thromboplastin time > 1.5 times the RI [11].