The assessed conditions include early-onset Alzheimer’s disease (EOAD), late-onset Alzheimer’s disease (LOAD), presenilin 1 (PS1) mutation carriers, three-repeat tauopathy (3Rtau), four-repeat tauopathy (4Rtau), frontotemporal lobar degeneration with TDP-43 type A pathology (TDP-43A), frontotemporal lobar degeneration with TDP-43 type C pathology (TDP-43C), and dementia with Lewy bodies (DLB) [159]. This evidence concerns the gene PSEN1 and early-onset autosomal dominant Alzheimer disease.