FOS and infarction: Furthermore, an early study indicated that deficiency in c-FOS increases infarct size and myocardial apoptosis leading to impaired cardiac function post-infarction [42], however another study implicated that c-FOS could regulate miR-27a which contributes to myocardial ischemia-reperfusion injury by regulated the translocation of apoptosis-inducing factor from the mitochondria to the nucleus [43].