As the overweight population has an increased risk of developing malignancies due to several dysfunctions such as hypoxia, prolonged inflammation, and metabolic imbalance, the study of programmed death ligand 1 (PD-L1) in obesity could represent an important step for further patient management [19,20,21,22]. The gene discussed is CD274; the disease is obesity due to melanocortin 4 receptor deficiency.