We assessed CXCL4, CXCL4–DNA and CXCL4–RNA complexes, anti-CXCL4 autoantibodies and IFN-α and TNF-α, which we call “CXCL4-related parameters” by ELISA at base line (T0) and at two different time points of treatments (three months, T3, and six months, T6) in SSc patients and in 19 HD (matched for age and sex). Here, PF4 is linked to systemic sclerosis.