Liposarcoma is a locally aggressive mesenchymal tumor composed of mature adipocytes and stromal cells with at least focal cytologic atypia with the following essential features: low-grade lipogenic tumor with multiple morphologic subtypes and significant histologic variability, molecularly characterized by ring or giant marker/rod chromosomes composed of material from 12q13-15, and the differential diagnosis is accomplished by the amplification of the murine double minute-2 (MDM2) gene [10]. Here, MDM2 is linked to mesenchymal cell neoplasm.