IRF4 and B-cell non-Hodgkin lymphoma: In the present case, t(6;18) might cause overexpression of BCL2 in the present case, which is associated with poor prognosis in DLBCL [22].Tamura et al. reported that FISH analysis of 173 cases of B-cell lymphoma detected IgH translocations in 70 cases (40.5%), and that 6p25 (MUM1/IRF4) was identified as a partner gene in one case [23].