Yet, for chemotherapy-insensitive primary refractory or early relapsing DLBCL, promising newly developed treatment approaches, including CD19-directed CAR-T-cell therapies and T-cell-engaging bi-specific CD3xCD20-directed antibodies, have recently been approved, changing the treatment landscape of refractory and relapsing DLBCL [14,15,16,17,18,19]. The gene discussed is CD19; the disease is diffuse large B-cell lymphoma.