In addition to hyperglycemia, some studies reported that maternal hypoglycemia identified during pregnancy might lead to decreased levels of human placental lactogen and reduced fetal insulin levels, creating an unfavorable environment for fetal growth and increasing the risk of adverse pregnancy outcomes, such as pre-eclampsia, fetal growth retardation, low birth weight (LBW), and low Apgar score [19–29]. This evidence concerns the gene INS and Hypoglycemia.