Following IR injury, Pepck-Cre+ Il1r1fl/fl mice (with proximal tubule–specific deletion of Il1r1) with or without LIPUS presented significantly milder kidney atrophy, tubular injury, and tubulointerstitial fibrosis compared with male Pepck-Cre– Il1r1fl/fl littermates (controls). The gene discussed is IL1R1; the disease is urogenital neoplasm.