Berberine can induce senescence in glioblastoma cells by inhibiting the epidermal growth factor receptor/mitogen-activated protein kinase kinase/extracellular regulated protein kinases (EGFR-MEK-ERK) pathway, and in colorectal cancer, it can also inhibit telomerase activity by downregulating hTERT, shortening telomere length [40,41]. The gene discussed is WNK2; the disease is colorectal cancer.