The evaluation of areas under the curves (AUCs) showed that all three variables (AOPPs, MM9, and NF-κB) predicted colon cancer with particularly significantly high performance (AUC = 0.912, 95% CI = 0.87–0.96, p < 0.0001 for AOPPs; AUC = 0.988 95% CI = 0.97–1.00, p < 0.0001 for MM9; AUC = 0.927 95% CI = 0.89–0.97, p < 0.0001 for NF-κB), with MM9 showing the highest predictive ability (Figure 6). The gene discussed is NFKB1; the disease is malignant colon neoplasm.