CLOCK and Alzheimer disease: For CLOCK gene rs4580704 [44], rs1554483 [45], rs4864548 [50] SNPs, BMAL1 gene rs2278749 [48], and BMAL2 gene rs2306074 [49] SNPs, the authors argued that they might contribute to increasing AD risk through dysregulation of metabolic pathways, potentially overlapping with APOE ε4-associated mechanisms, and possibly exacerbating neurodegeneration via impaired glucose [53] and lipid [54] metabolisms, and an increase in metabolic syndrome risk [55].