A study by Luo et al. demonstrated that sleep deprivation (SD) upregulated Cry2 in the hippocampus of AD mice by decreasing cytokine-inducible SH2-containing protein (CISH)-mediated transcription factor Signal Transducer and Activator of Transcription 1 (STAT1) phosphorylation, which resulted in synaptic dysfunction [41]. This evidence concerns the gene STAT1 and Alzheimer disease.