PPARG and obesity due to melanocortin 4 receptor deficiency: Furthermore, miR-27 has been shown to inhibit adipocyte differentiation by targeting PPARγ [192], miR-375 prevents HFD–induced obesity by targeting the aryl hydrocarbon receptor and the bacterial tryptophanase gene [193], whereas miR-22 drives thermogenic function in BAT by regulating glycolysis and thermogenic genes via the hypoxia-inducible factor 1α (HIF1α) and mechanistic target of rapamycin complex 1 (mTORC1) signaling pathways [194].