SMAD3 and obesity due to melanocortin 4 receptor deficiency: Moreover, in subcutaneous adipose tissue and circulating leukocytes, the methylation levels of fibroblast growth factor receptor-like 1 (Fgfrl1), non-SMC condensin II complex subunit H2 (Ncaph2), paroxysmal nonkinesigenic dyskinesia (Pnkd), and SMAD family member 3 (Smad3) exhibit strong and statistically significant efficiencies in distinguishing obesity from non-obese status, as well as a great correlation between both tissues [74].