Building on this potential, our previous study identified three significant cfRNA biomarkers comprising HPGD (hydroxyprostaglandin dehydrogenase), PACS1 (Phosphofurin Acidic Cluster Sorting Protein 1), and TDP2 (tyrosyl-DNA phosphodiesterase 2) via the RNA sequencing (RNA-seq) of plasma samples from a small cohort of CRC patients. Here, TDP2 is linked to colorectal carcinoma.