GBE1 and glycogen storage disease due to glycogen branching enzyme deficiency: In contrast, Andersen Disease, or Glycogen Storage Disease Type IV (GSD IV) and its adult-onset counterpart Adult Polyglucosan Body Disease (APBD), are autosomal recessive disorders that affect mitochondrial function indirectly through mutations in the GBE1 gene, which encodes the glycogen branching enzyme (GBE).