Shang et al. discovered that inhibiting miR-874-5p expression increases VDR expression, reduces NLRP3 expression, decreases caspase-1 activation and IL-1β secretion, and alleviates pyroptosis and inflammatory responses, thereby protecting from intestinal barrier damage in sepsis—all of which can be reversed by downregulating VDR [244]. This evidence concerns the gene VDR and Sepsis.