Researchers indicate that VDD or VD insufficiency is linked to an increased susceptibility to sepsis and poorer clinical outcomes, including greater sepsis severity, higher mortality rates, prolonged hospital and ICU stays, and negative correlations with lactate, CRP, acute physiology and chronic health evaluation II (APACHE II), and sequential organ failure assessment (SOFA) scores, as well as longer durations of mechanical ventilation [25,29,30,31,32,33,34,35,36,37,38,39,40,41]. This evidence concerns the gene CRP and Sepsis.