AKT1 and non-small cell lung carcinoma: In NSCLC cell lines (HCC827 (EGFR Del E746-A750), H1975 (EGFR L858R/T790M), H3255 (EGFR L858R), A549 (EGFR WT), and H1299 (EGFR WT), formononetin was shown to promote the efficacy of EGFR-TKI by modulating the EGFR-AKT-Mcl-1 axis in a ubiquitination-dependent manner [101].