Contrary to some studies [47,59] showing that serum SHBG levels were inversely related to the individual components of metabolic syndrome, except for blood pressure, our results supported the notion that genetic predisposition to higher SHBG levels were favorable with SBP and DBP, and these two traits mediated the greater effects of genetically determined SHBG on any stroke or ischemic stroke. The gene discussed is SHBG; the disease is Stroke.