SHBG and type 2 diabetes mellitus: In the replication datasets, the protective effects of SHBG on WC (β = −0.039; 95% CI: −0.057, −0.021; p = 2.04 × 10−5), WHR (β = −0.065; 95% CI: −0.094, −0.036; p = 2.56 × 10−5), FG (β = −0.029; 95% CI: −0.049, −0.009; p = 0.006), TG (β = −0.131; 95% CI: −0.213, −0.049; p = 0.002), SBP (β = −0.055; 95% CI: −0.075, −0.035; p = 1.70 × 10−8), DBP (β = −0.027; 95% CI: −0.041, −0.013; p = 9.37 × 10−5), and T2DM (OR = 0.834; 95% CI: 0.749, 0.918; p = 2.27 × 10−5) were further verified, with the final IVs of SHBG levels ranging from 33 to 189.