Furthermore, genetically determined higher WC had a positive impact on any stroke (OR = 1.135; 95%CI: 1.016, 1.255; p = 0.037) and ischemic stroke (OR = 1.236; 95%CI: 1.122, 1.350; p = 2.36 × 10−4), contributing 18.9% and 38.6% to the total effect of SHBG levels on any stroke and ischemic stroke, respectively. The gene discussed is SHBG; the disease is ischemic stroke.