Genetically elevated SHBG levels were associated with a lower risk of any stroke (OR = 0.941; 95% CI: 0.898, 0.984; p = 0.005), any ischemic stroke (OR = 0.951; 95% CI: 0.922, 0.981; p = 0.013), and small-vessel stroke (OR = 0.871; 95% CI: 0.765, 0.977; p = 0.010), but not with cardioembolic stroke (OR = 0.991; 95% CI: 0.903, 1.079; p = 0.838), large-artery stroke (OR = 0.932; 95% CI: 0.819, 1.046; p = 0.227), or intracerebral hemorrhage (OR = 0.810; 95% CI: 0.473, 1.147; p = 0.219). This evidence concerns the gene SHBG and ischemic stroke.