We also observed increased MHC class II gene expression in the cMBCs (HLA-DQA2, HLA-DRB6) (Supplemental Figure 4A) and MZ-like B cells (HLA-DQA2, HLA-DRB5) (Supplemental Figure 4B) of patients with IBD (anti-IL-12/23 or anti-TNF treated) compared with people in the healthy control group. This evidence concerns the gene TNF and inflammatory bowel disease.