We not only detected enriched macrophages as CD68+ cells in TD-PCLS compared with healthy PCLS (Figure 3E), but also documented the subpopulations of antitumor M1 macrophages (IL8) and tumor-promoting M2 macrophages (ALOX15 or CD206) in TD-PCLS (Supplemental Figure 2A), as to be expected for lung tumor tissue (21). This evidence concerns the gene MRC1 and neoplasm.