TTR and chronic kidney disease: ATTRv can also lead to extracellular deposition of amyloid proteins in kidney tissues resulting in proteinuria and CKD.3,6 Most studies describing the impact of ATTRv on the kidney focused on the TTR Val30Met mutation which is the most common mutation of ATTRv worldwide and is found predominantly in Portuguese populations.3 Kidney involvement in patients with TTR Val122Ile mutations has been studied in less detail.