YAP1 and primary ovarian failure: Consistent with this, dysregulation of β-catenin and Hippo/Yap1 has been shown in conditions of disrupted follicle growth including PCOS (Ji et al., 2017), as well as Primary Ovarian Insufficiency (POI) and fibrosis (Kawamura et al., 2013; Matsuzaki and Darcha, 2013).