The majority of lncRNAs and mRNAs exhibited both cancer-specific and stage-specific synergistic interactions, whereas a few, such as RBM6, IGF2BP2, MALAT1, and FENDRR, demonstrated synergy in >10 cancer types and in all four stages (Fig. 1d and e), suggesting their broad regulatory roles in multiple cancer progression. This evidence concerns the gene IGF2BP2 and cancer.