The expression of other key atherosclerosis-related enzymes, including cytochrome P450 8B1 (CYP8B1) and lanosterol synthase (LSS), was downregulated, whereas the expression of cyclooxygenase 2 (COX-2) and aldo–keto reductase family 1 member C3 (AKR1C3) was induced by PFOS and PFOA. This evidence concerns the gene CYP8B1 and atherosclerosis.