Similarly, tumors formed by COL17A1-deficient MGH1275 cells were significantly smaller compared with NTC tumors, with a reduction in tumor weight of 79% and 81% and a reduction in size of 73% and 81% for shRNA#1 and shRNA#2, respectively (P < 0.0001; Fig. 5A, E, and F). This evidence concerns the gene COL17A1 and neoplasm.