Univariable logistic regression analysis demonstrated CD3+ T cells percentages (OR = 1.048, 95% CI 1.014–1.083, p = 0.005), CD3+CD8+ T cells percentages (OR = 1.052, 95% CI 1.015–1.090, p = 0.005), CD19+ B cells percentages (OR = 0.947, 95% CI 0.914–0.982, p = 0.003) were associated with corticosteroids resistance of CTD‐ITP. The gene discussed is CD8A; the disease is autoimmune thrombocytopenic purpura.