,43 We recently identified that the precursor of brain-derived neurotrophic factor elevated in antibody-secreting B cell subsets drives the development of systemic lupus erythematosus in a p75NTR-dependent manner,15 highlighting an immune-modulating role of proBDNF-p75NTR signaling in B cells. This evidence concerns the gene NGFR and systemic lupus erythematosus.