On the basis of these protein functionsand the ability of cancer cells to migrate by altering their cytoskeletonand adhesion properties or interacting with EMC, in addition to inhibitingapoptosis, we suggest that the phytochemicals present in K. pinnata may function to decrease the activationof migration, growth and survival signal transduction pathways, includingthe MAPK, PI3K/AKT, and JAK2/STAT3 pathways, which are required forcancer cell maintenance, mainly in HCC937 cells (Figures  and ). The gene discussed is PIK3CA; the disease is cancer.