Interestingly, T2DM can alsobe considered an aggregopathy sinceit has been associated with the presence of aggregated pancreaticislet amyloid polypeptide (IAPP). Alsoknown as amylin, physiological IAPP is responsible for both the regulationof food intake and the transmission of signals to the central nervoussystem. This 37-residue amino acid peptideis secreted by the β-cells of pancreatic islets and is usually present in increased concentrations in insulinresistance conditions. Amyloid depositsof IAPP constitute a histological hallmark of T2DM, found in over90% of patients., Here, IAPP is linked to type 2 diabetes mellitus.