Type 2 diabetes mellitus (T2DM) is a chronic endocrinedisorder characterized by hyperglycemia, which may result from defectsin the secretion or action of insulin. Although many patients are asymptomatic, clinical manifestationsincluding unintended weight loss, fatigue, blurred vision, and numbnessin the hands or feet are possible. The gene discussed is INS; the disease is type 2 diabetes mellitus.