Using a murine macrophage (J774A.1) infection model, we evaluated phagocytosis, intracellular survival, cell damage, and the expression of six immune-related genes (TNF-α, CCL20, RELA, TP53, NLRP3, IL-1β), in comparison with P. americana and P. verrucosa. The gene discussed is TP53; the disease is infection.