Guo et al. (2011) demonstrated that RPS13 suppresses the cell-cycle inhibitor p27 (Kip1) in cancer cells, and our data suggest a conserved mechanism in FPVEs. Reduced RPS13 expression in GDM may elevate p27 (Kip1) levels, arresting endothelial cells in the G1 phase and impairing angiogenesis, a process vital for placental vascular remodeling (Tan et al., 2024). This evidence concerns the gene RPS13 and gestational diabetes.