Increased Tau phosphorylation in the brain is a typical feature of AD, but alterations of phospho-Tau levels in the hippocampus were also observed during LPS-evoked systemic inflammation in mice (Czapski et al., 2016) and in adolescent rats after LPS-evoked MIA (Cieślik et al., 2020a). The gene discussed is MAPT; the disease is Alzheimer disease.