Multiple hypotheses have been advanced to explain the underlying mechanisms of AD, including dysfunction in cholinergic and glutamatergic neurotransmission, the role of infections and inflammatory processes, amyloid and/or Tau propagation and accumulation, lymphatic system involvement, neurovascular changes, calcium dyshomeostasis, metal ion imbalance, and the mitochondrial dysfunction (Liu et al., 2019; Yokoyama et al., 2022). The gene discussed is MAPT; the disease is Alzheimer disease.