Similarly, another study showed that suppression of circ-RPL15 inhibits the RAS/RAF1/MEK/ERK pathway via miR-146b-3p This interaction indicates a connection between RAF1, miR-146b-3p, and Circ-RPL15 in chronic lymphocytic leukemia (CLL) [11]. The gene discussed is MAP2K7; the disease is B-cell chronic lymphocytic leukemia.