Several pathways, including the phosphatase and tensin homolog deleted on chromosome ten/the mammalian target of rapamycin (PTEN/mTOR), signal transducer and activator of transcription 3/mitogen-activated protein kinase/extracellular signal-regulated kinases (STAT3/MEK/ERK), or Janus-activated kinases/signal transducers and activators of transcription (JAK/STAT), are used to down-signalize self-activated glioma cells. This evidence concerns the gene STAT3 and glioma.