Tumor rot factor-alpha (TNF- α±), interleukin (IL)-1α ± and 1β, IL-4, IL-6, IL-8, chemokines (e.g., CXCL-12), cyclooxygenase-2 (COX2), prostaglandin (PG) E2, and platelet-derived development calculate (PDGF) are among the variables determined from gliomas that are vital incendiary go-betweens that start the incendiary cycle in GBM and advance empower carcinogenesis by escaping development concealment, advancing angiogenesis and metastasis, upsetting apoptosis, and protecting the stemness of cancer cells [134,135]. This evidence concerns the gene CXCL12 and central nervous system cancer.