SLC39A3 and Alzheimer disease: Therefore, given the critical role of zinc homeostasis in neuronal pathophysiology, together with the predicted importance of cation exchange in ISR and synaptoplasticity, we decided to perform in vitro validation of SLC30A4. This transcript, together with SLC39A3, encodes for zinc transporters (zinc transporter 4 (ZnT4) and ZIP3, respectively), and both have already been associated with neurodegeneration processes [84], [85] and AD [86], [87].