GPC3 and cerebral amyloid angiopathy: Heparan sulphate proteoglycans, which highlights as the most overrepresented biological process, has been found to be elevated in the cerebrovasculature of AD patients with severe cerebral amyloid angiopathy [69], and they have been proposed to play a role in tau protein aggregation to form the neurofibrillary tangles, a hallmark of AD [70].