NFKB1 and cardiovascular disorder: In addition, enrichment analysis showed that the marker genes associated with macrophage regulation and carotid plaque progression were significantly enriched in inflammation-related signaling pathways, such as TLRs, NF-κB, etc. TLRs are a family of type-recognition receptors that function crucially in autoimmune responses and serve as a bridge between the development of cardiovascular diseases and the immune system [35].